Wednesday, May 19, 2010

Cows on Drugs



http://www.youtube.com/watch?v=Dmg_yggrgVM

Key Ideas:

  • In 2005, one class of antibiotics, fluoroquinolones, was banned in the production of poultry in the United States, but the total number of antibiotics used in agriculture is continuing to grow.
  • Many associations are urging Congress to phase out the nontherapeutic use in livestock of antibiotics that are important to humans.
  • Congress should now pass the Preservation of Antibiotics for Medical Treatment Act, which would ban industrial farms from using seven classes of antibiotics that are important to human health under certain conditions.
  • The pharmaceutical industry and agribusiness face the difficult challenge of developing antimicrobials that work specifically against animal infections without undermining the fight against bacteria that cause disease in humans.
Reflection:
I thought this article was hard to read because it didn't hold my attention for long. It is an interesting topic, but the the author used too many long words that made the article draw out longer. It was about trying to stop people from giving human antibiotics to animals to improve their production. I think this is important that this should be done so that people won't get sick as much and there won't be as many deaths from antibiotic poisoning from animals. This course helped me to understand this topic because we studied genetically modified organisms.

MLA: Kennedy, Donald. "Cows on Drugs."
The New York Times - Breaking News, World News & Multimedia. 12 May 2010. Web. http://www.nytimes.com/2010/04/18/opinion/18kennedy.html.

Tuesday, May 18, 2010

EXPERT ASSESSMENT - Law Seeks to Ban Misuse of Genetic Testing

PART ONE: ARTICLE SUMMARY

Key Ideas:

  • A new law, the Genetic Information Nondiscrimination Act, will take effect in the nation’s workplaces on Nov. 21, 2009 for employers with 15 or more employees.
  • This law prohibits employers from requesting genetic testing or considering someone’s genetic background in hiring, firing or promotions and health insurers from requiring such testing or using genetic information to deny coverage or set deductibles.
  • Genetic tests help determine whether someone is at risk of developing an inherited disease or medical condition.
  • Congress passed the new law last year because many Americans feared that their employers would discriminate against them because of their genetic history.
  • The act includes a “water cooler” exception, as in a case where a manager overhears one employee telling another that his father had a stroke.
This course prepared me to better understand this article through our course on genetics. We studied that people inherit their genes and DNA from their parents. Some people also inherit certain tendencies of getting diseases easier than someone else might get the disease. Also, people's genetics can help to determine a person's occupation, like if certain working conditions would cause severe health problems for a certain person.

People, Agencies, etc.
  • John C. Stivarius Jr.
  • J. D. Piro, a principal in the Health Care Law Group at Hewitt Associates
  • Peggy R. Mastroianni, associate legal counsel for the Equal Employment Opportunity Commission
  • Christopher Kuczynski, assistant legal counsel with the commission
  • Sharon F. Terry, chairwoman of the Coalition for Genetic Fairness
  • Burlington Northern and Santa Fe Railway Company
  • David Escher
  • Michael P. Aitken, director of governmental affairs for the Society of Human Resource Management
  • Mr. Stivarius, the Atlanta lawyer
  • Susan Pisano, a spokeswoman for America's Health Insurance Plans

Type of Article:

This article is none of those listed on the sheet. Instead, it is a report on a new law passed. This law prohibits employers from testing their employees' genetic histories. This article is from November of 2009, so it is currently in effect.

MLA: Greenhouse, Steven. "The New York Times." New York Times 16 Nov. 2009: B5. The New York Times - Breaking News, World News & Multimedia. 15 Nov. 2009. Web. http://www.nytimes.com/2009/11/16/business/16genes.html.



PART TWO: BACKGROUND RESEARCH

Article #1: Conn. woman alleges genetic discrimination at work
MLA: Reitz, Stephanie. "The Associated Press: Conn. Woman Alleges Genetic Discrimination at Work." Google. 28 Apr. 2010. Web. http://www.google.com/hostednews/ap/article/ALeqM5idLXFbznBv57CnEMaLryCjkfjAgQD9FCA2T80.

Summary:
This article is about a Connecticut woman who had a voluntary double mastectomy after genetic testing. She is alleging her employer of eliminating her job after learning she carried a gene implicated in breast cancer. Her complaints are among the first known to be filed nationwide based on the federal Genetic Information Nondiscrimination Act. Pamela Fink told her bosses at MXenergy about her genetic tests and the surgery, and then they fired her. She said her job was eliminated — the only one in her department — and she was escorted out in March, about six weeks after she returned from her second surgery. Catherine Barbieri, a Philadelphia attorney specializing in anti-discrimination employment law, said the Connecticut case is the first she's heard about nationwide that cites the genetic tests law. This is totally wrong of companies to do. Judging people by their genetic background is just as bad as being racist or sexist. The Genetic Information Nondiscrimination Act has been applied for one of the first times.


Article #2: Discrimination Claims Rising in Wake of Genetic Bias Law
MLA: Greenwald, Judy. "Discrimination Claims Rising in Wake of Genetic Bias Law " Business Insurance News, Analysis & Articles. May 2010. Web. http://www.businessinsurance.com/article/20100516/ISSUE01/305169979.

Summary:
This article is about more lawsuits involving the Genetic Information Nondiscrimination Act. Even after knowing about the law, many companies continued to perform genetic tests on their employees. It says that the Equal Employment Opportunity Committee is expected to issue final rules in connection with GINA soon. So far, the EEOC has received about 80 GINA-related claims. They expect to receive a huge wave of complaints relating to infractions of the GINA by companies who continue to perform genetic tests on their employees. Employees aren't the only victims in this situation -- employers have to be careful about being set up by their employees volunteering genetic information and then alleging that was the cause of a subsequent adverse job action. The EEOC is being very proactive in their efforts in pursuing claims that they can control. Since the law passed during a period of economic turmoil, employers haven't put much emphasis on it. Employers need to be more careful in their pursuits to genetically test their employees, while employees need to be more careful in letting information slip about their genetic history.



PART THREE: ANALYSIS OF POTENTIAL BIAS

1. Bias through selection and omission

This article selected to write from the standpoint of the victims -- the people. It portrays the employers as the ones causing all the lawsuits. However, that is not always the case. The employees sometimes let on a little too much about their genetic history, and they give their employers reason to test them and fire them. This article shows the companies as greedy when the "boss [says] the company could not afford to keep [an employee] if the results were positive." That's just not fair.

2. Bias through placement

This article focused on the positive effects caused by this law. It talked about how it prevents unfair treatment of employees with certain genetic backgrounds. There really aren't any negative effects of this law, and the article proved that by talking about how more people would be able to keep their jobs. Even though the law has many positive effects, we are yet to find out if there are any negative things about it.

3. Bias by headline

The headline of this article accurately summarizes this article. It approves of the law, and shows that genetic testing is being misused by people. It is a very biased headline, implying that the law will be great for all people because they will not have to be discriminated against because of their genetic background.

4. Bias by photos, captions, and camera angles

There is one picture included in this article. It shows a man who got let go from his job because his employer found out that he had developed carpal tunnel syndrome. The picture portrays the man with a smile on his face, but it doesn't look real. There seems to be some worry in his eyes. His pose looks fixed and un-humanlike as well.

5. Bias through use of names and titles

This article does not use specific names to degrade certain people. The writer of this story used average people and large companies to get his point across. It was almost as if the writer was channeling his inner child when he makes it seem like the company/employer as the bully and the employee as the defenseless child.

6. Bias through statistics and crowd counts

This article gives this statistic: "In a nationwide survey, 63 percent of respondents said they would not have genetic testing if the employers could see the results." This statistic is biased in the number it gives. The writer is the only person who knows what the percent of the statistic is, so it could be higher or lower. This statistic doesn't seem too biased though because the number is reasonable -- it is a majority, but not overpowered by the minority. If people see that stat, they will think they need to support the cause so the number will go up for of fear of defeat.

7.Bias by source control

This story comes from the New York Times, which is a highly regarded newspaper source. I haven't heard the name of this author many times before, so he may have used too much opinion in this article. This author was most likely briefed on the story then told to write a story on it. During his briefing, he was probably introduced to bias that supports the law. Therefore, his sources are biased towards supporting the new law, and his story was based upon that bias.

8.Bias by word choice and tone

This author uses promotive and positive words when talking about the law. He also uses this type of words when talking about supporting the employees. He uses degrading and negative words when talking about the companies and employers conducting the genetic tests. The author wants the reader to take caution with their employers and cautions them to avoid the kinds of situations when they have to get tested for their genetic background.

Speed Reading of DNA May Help Cancer Treatment



http://www.cbsnews.com/video/watch/?id=4580875n


Key Ideas:
  • Researchers at Johns Hopkins University have developed a way to monitor the progress of a patient’s cancer treatment using a new technique for sequencing large amounts of DNA.
  • The DNA rearrangements are unique to cancer cells, making them a very specific marker.
  • More than 80 percent of cancers had mutations in their mitochondrial DNA.
  • The proportion of variant mitochondrial DNA in healthy people tended to vary quite widely from one kind of tissue to another.
  • If two mitochondrial DNA sequences differ by a single unit, current guidelines require the analyst to report the comparison as inconclusive.
Reflection:
I thought this article was pretty boring. Even though it is a scientific breakthrough, I feel like there are too many. I mean, it's cool that science has come so far, but something seems off. It's good that these scientists are relating their discoveries to outside of the scientific world and using them to further research in other areas. By doing this, ideas get passed back and forth, and that will most likely lead to another discovery. The cycle seems like it's unending. This course helped me to understand this topic because we studied DNA and cancer.

MLA: Wade, Nicholas. "Speed Reading of DNA May Help Cancer Treatment." The New York Times - Breaking News, World News & Multimedia. 08 Mar. 2010. Web. http://www.nytimes.com/2010/03/09/science/09gene.html.

Monday, May 17, 2010

White Lizards Evolve in New Mexico Dunes


http://c0508042.cdn.cloudfiles.rackspacecloud.com/100105Lizard.jpg

Key Ideas:
  • Erica Bree Rosenblum's focus is on three lizard species that elsewhere are dark skinned but in White Sands have each evolved a white-skinned variety that makes them hard to find.
  • In at least two of the lizard species, the researchers found that mutations on the same gene, linked to the production of skin pigment, were responsible.
  • In the two of the lizard species, mutations on the same gene, linked to the production of skin pigment, were responsible.
  • In the two species, there are two molecular mechanisms. In one, the mutation has made the white-skinned trait dominant; in the other, the mutation has made it recessive.
Reflection:
I think that this article wasn't uninteresting, but it wasn't interesting either. I find it pretty amazing that this lizard could drastically change colors like that. I don't think a human could go through a change like that. If that happened, all humans would constantly be changing skin colors depending on where they live. That would be quite weird. There is an allele interaction that causes the lizards skin color to change - dominant/recessive. The skin pigment is an evolutionary trait that is a part of survival of the fittest. This course helped me to understand this topic because we studied evolution.

MLA:Fountain, Henry. "White Lizards Evolve in New Mexico Dunes." The New York Times - Breaking News, World News & Multimedia. 4 Jan. 2010. Web. http://www.nytimes.com/2010/01/05/science/05oblizard.html.

Gladwell Digs into Cancer Drug Research Difficulties


http://blogs.wsj.com/health/2010/05/10/gladwell-digs-into-cancer-drug-research-difficulties/?KEYWORDS=cancer

Key Ideas:
  • 90% of the drugs studied in humans to fight cancer show no difference between the control and treatment arms.
  • Malcolm Gladwell points out that given the pitfalls of cancer drug development, a “master code behind the disease” may not be waiting to be cracked.
  • The drug, which causes cancer cells so much oxidative stress that they die, showed promise in the lab.
  • The company recently announced that the FDA has allowed it to resume clinical development of elesclomol.
  • Gladwell has to work backward to find a solution, and that will be difficult because he does not have an understanding of cancer, just like other scientists.
Reflection:
I found the statistic given at the beginning of the article to be surprising. If there was a choice t have your disease treated or controlled, and chose to have it treated, it's sort of a waste because the two drugs are the same. I think its important that someone is looking for a solution to the problem of cancer. Drugs can only help a person fight the disease for so long, because there is no sure cure for the disease. The FDA shouldn't have approved the development of elesclomol because it will be harmful to the people who put that into their bodies.This course helped me to understand this topic because we studied cancer.

MLA: Hobson, Katherine. "Gladwell Digs into Cancer Drug Research Difficulties - Health Blog - WSJ." WSJ Blogs - WSJ. Wall Street Journal, 10 May 2010. Web. http://blogs.wsj.com/health/2010/05/10/gladwell-digs-into-cancer-drug-research-difficulties/?KEYWORDS=cancer.

University of Bristol scientists DNA test unique tree



http://news.bbc.co.uk/local/bristol/hi/people_and_places/nature/newsid_8620000/8620605.stm

Key Ideas:
  • Scientists from the University of Bristol have used genetics to explain the evolution of a unique tree species that is only found in Avon Gorge.
  • By studying the trees' DNA, the Professor Hiscox and his team showed that these trees are cross-breeding with each other, and these hybrids reproduce asexually, in an ongoing process that adds to the diversity of Sorbus trees found in the gorge.
  • Professor Hiscock said: "The Sorbus tree breeding system plays a critical role in determining the likelihood of their long-term survival."
  • Their findings are helping to guide the work of Avon Gorge and Downs Wildlife Project and the National Trust to aid the conservation of these rare species.
  • The identification and preservation of such dynamic evolutionary processes will be essential for maintaining biodiversity.
Reflection:
This article was about the Sorbus tree that produces asexually. It is only found in one city in Britain which it pretty cool. These trees cross-breed with each other, and these hybrids then reproduce asexually to create diversity. It seems as if these trees are altering the evolutionary process to adapt to their environmental conditions. By altering the evolutionary process, this species of tree manages to survive in one environment that goes unchanging most of the time. I find that interesting because all other organisms have to adapt to their surroundings while this one does not. This course helped me to understand this topic because we studied DNA in the genetics unit and evolution.

MLA: "BBC - University of Bristol Scientists DNA Test Unique Tree." BBC NEWS | News Front Page. Bristol University, 14 Apr. 2010. Web. http://news.bbc.co.uk/local/bristol/hi/people_and_places/nature/newsid_8620000/8620605.stm.

Portrait in DNA: Can forensic analysis yield police-style sketches of suspects?



http://www.youtube.com/watch?v=SlZ5bF3opQ4

Key Ideas:
  • The analysis marks the first full sequencing of an ancient human genome and offers an example of how much detectives can discover just from a suspect’s genetic code.
  • The researchers resolved a debate about the origins of Greenland’s paleo-Eskimos by showing he had a pattern of DNA variations most common in Siberian population groups.
  • Having more to go on than ancestry is the goal of some programs that fund research into alternative genetic markers for forensic use.
  • An important feature in profiling has hereditary roots but also depends on environmental factors, such as nutrition during childhood.
  • Skin-deep is as far as a DNA sketch should go, according to some bioethicists.
Reflection:
I think this article was pretty interesting to read. Using DNA to help solve forensic cases is really intense. Science truly has come such a long way and it's now used for things that used to be impossible. This article implies that DNA will continue to be useful in forensic analysis and will have an even more important role in the future. This article makes me wonder what will happen in the future. Because scientific technology has developed so much in a span of 10 years, we can only imagine how much more will be developed in another 10 years. This course helped me to understand this topic because we studied genetics and DNA.

MLA: Soares, Christine. "Portrait in DNA: Can Forensic Analysis Yield Police-style Sketches of Suspects?: Scientific American." Scientific American May 2010. Science News, Articles and Information | Scientific American. Web. http://www.scientificamerican.com/article.cfm?id=portrait-in-dna.